Neuroinflammatory markers: key indicators in the pathology of neurodegenerative diseases
Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
SB Chidambaram, MM Essa, AG Rathipriya… - Pharmacology & …, 2022 - Elsevier
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …
The role of the inflammasome in neurodegenerative diseases
F Piancone, F La Rosa, I Marventano, M Saresella… - Molecules, 2021 - mdpi.com
Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …
nervous system (CNS). They are characterized by the loss of neuronal structure and function …
Interactome mapping provides a network of neurodegenerative disease proteins and uncovers widespread protein aggregation in affected brains
Interactome maps are valuable resources to elucidate protein function and disease
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …
[HTML][HTML] Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
U Fatima, S Roy, S Ahmad, LA Al-Keridis… - Biomedicine & …, 2022 - Elsevier
Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda
system; it contains numerous bioactive phytoconstituents implicated in the therapeutic …
system; it contains numerous bioactive phytoconstituents implicated in the therapeutic …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Neurodegenerative diseases as proteinopathies-driven immune disorders
F Ciccocioppo, G Bologna, E Ercolino… - Neural Regeneration …, 2020 - journals.lww.com
In the pathophysiology of neurodegenerative disorders, the role of misfolded protein
deposition leading to neurodegeneration has been primarily discussed. In the last decade …
deposition leading to neurodegeneration has been primarily discussed. In the last decade …
A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases
Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …
found in the brain and plays a significant role in developing the central nervous system …
Investigating MARK4 inhibitory potential of Bacopaside II: targeting Alzheimer's disease
S Anwar, T Mohammad, MK Azhar, H Fatima… - International journal of …, 2023 - Elsevier
Microtubule affinity regulating kinase 4 (MARK4) is known to hyperphosphorylate tau
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …
protein, which subsequently causes Alzheimer's disease (AD). MARK4 is a well-validated …
Neuroprotective Effects of Palmatine via the Enhancement of Antioxidant Defense and Small Heat Shock Protein Expression in Aβ‐Transgenic Caenorhabditis …
W Jia, Q Su, Q Cheng, Q Peng, A Qiao… - Oxidative Medicine …, 2021 - Wiley Online Library
Palmatine is a naturally occurring isoquinoline alkaloid that has been reported to display
neuroprotective effects against amyloid‐β‐(Aβ‐) induced neurotoxicity. However, the …
neuroprotective effects against amyloid‐β‐(Aβ‐) induced neurotoxicity. However, the …