The role of IL‐17 and related cytokines in inflammatory autoimmune diseases
T Kuwabara, F Ishikawa, M Kondo… - Mediators of …, 2017 - Wiley Online Library
Interleukin‐17 (IL‐17) induces the production of granulocyte colony‐stimulating factor (G‐
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap
Although great success has been obtained in the clinic, the current immune checkpoint
inhibitors still face two challenging problems: low response rate and immune-related …
inhibitors still face two challenging problems: low response rate and immune-related …
Secukinumab in plaque psoriasis—results of two phase 3 trials
RG Langley, BE Elewski, M Lebwohl… - … England Journal of …, 2014 - Mass Medical Soc
Background Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We
evaluated secukinumab, a fully human anti–interleukin-17A monoclonal antibody, in …
evaluated secukinumab, a fully human anti–interleukin-17A monoclonal antibody, in …
Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders
HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …
are highly variable and are clinically characterized by deficits in social interactions …
Cytokines in psoriasis
J Baliwag, DH Barnes, A Johnston - Cytokine, 2015 - Elsevier
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …
mRNA delivery of a bispecific single‐domain antibody to polarize tumor‐associated macrophages and synergize immunotherapy against liver malignancies
Liver malignancies are among the tumor types that are resistant to immune checkpoint
inhibition therapy. Tumor‐associated macrophages (TAMs) are highly enriched and play a …
inhibition therapy. Tumor‐associated macrophages (TAMs) are highly enriched and play a …
[HTML][HTML] Stapled peptides inhibitors: a new window for target drug discovery
AM Ali, J Atmaj, N Van Oosterwijk, MR Groves… - Computational and …, 2019 - Elsevier
Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …
Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics
The understanding of the foreign-body responses to implanted biomaterials would benefit
from the reconstruction of intracellular and intercellular signalling networks in the …
from the reconstruction of intracellular and intercellular signalling networks in the …