Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19

S Wolfisberg, C Gregoriano… - Critical reviews in clinical …, 2022 - Taylor & Francis
Procalcitonin (PCT) is useful for differentiating between viral and bacterial infections and for
reducing the unnecessary use of antibiotics. As the rise of antimicrobial resistance reaches …

Host diagnostic biomarkers of infection in the ICU: where are we and where are we going?

AJ Heffernan, KJ Denny - Current infectious disease reports, 2021 - Springer
Abstract Purpose of Review Early identification of infection in the critically ill patient and
initiation of appropriate treatment is key to reducing morbidity and mortality. On the other …

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa …

J Chastre, B François, M Bourgeois, A Komnos… - Critical Care, 2022 - Springer
Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in
hospitalised patients is associated with high mortality. The effectiveness of the bivalent …

Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

L Agnello, G Bivona, M Vidali, C Scazzone… - Clinical Chemistry and …, 2020 - degruyter.com
Objectives The diagnosis of sepsis in the Emergency Department (ED) is challenging and a
reliable biomarker is needed. The current study aimed to evaluate the diagnostic accuracy of …

The pathophysiology of sepsis—2021 update: Part 2, organ dysfunction and assessment

J Jacobi - American Journal of Health-System Pharmacy, 2022 - academic.oup.com
Purpose This is the second article in a 2-part series discussing the pathophysiology of
sepsis. Part 1 of the series reviewed the immunologic response and overlapping pathways …

The ability of Procalcitonin, lactate, white blood cell count and neutrophil-lymphocyte count ratio to predict blood stream infection. Analysis of a large database

PE Marik, E Stephenson - Journal of Critical Care, 2020 - Elsevier
Background The global burden of death due to sepsis is considerable. Early diagnosis is
essential to improve the outcome of this deadly syndrome. Yet, the diagnosis of sepsis is …

Prediction of severe CRS and determination of biomarkers in B cell-acute lymphoblastic leukemia treated with CAR-T cells

Z Wei, J Xu, C Zhao, M Zhang, N Xu, L Kang… - Frontiers in …, 2023 - frontiersin.org
Introduction CAR-T cell therapy is a novel approach in the treatment of hematological
tumors. However, it is associated with life-threatening side effects, such as the severe …

Comparison and analysis of polymer-functionalized carbon nanotubes for enhancement of the quantitative detection of procalcitonin levels in human plasma

A Schuck, HE Kim, M Kang, YS Kim - BioChip Journal, 2023 - Springer
Procalcitonin (PCT) is one of the core biomarkers for the body's systemic inflammatory
response that is expressed uniformly in several organ tissues. PCT concentration levels rise …

Platelet indices and their kinetics predict mortality in patients of sepsis

S Mangalesh, S Dudani, A Malik - Indian Journal of Hematology and Blood …, 2021 - Springer
Platelet indices are inexpensive, easily accessible parameters and potentially useful
prognostic indicators in sepsis. In this study we explore the differences in platelet indices …

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T‐cell therapy recipients

MZ Powell, KC Mara, R Bansal, MA Hathcock… - Cancer …, 2023 - Wiley Online Library
Background It is unknown whether serum procalcitonin (PCT) concentration monitoring can
differentiate between bacterial infection or cytokine release syndrome (CRS) when chimeric …