Pulmonary arterial hypertension (PAH) is a rare, serious, and incurable disease
characterized by high lung pressure. PAH-approved drugs based on conventional pathways …

Combination therapy with oral administration of several active ingredients is a popular
clinical treatment for cancer. However, the traditional method has poor convenience, less …

Dichloroacetate (DCA) is an investigational drug used to treat lactic acidosis and malignant
tumours. It works by inhibiting pyruvate dehydrogenase kinase and increasing the rate of …

Oleanolic acid (OA) is the main triterpenic acid of olive leaves known for numerous
pharmacological properties, including antioxidant activity. However, it is poorly soluble in …

Background The anti-Programmed Death-Ligand 1 (termed aPD-L1) immune checkpoint
blockade therapy has emerged as a promising treatment approach for various advanced …

Vaccination has emerged as the most effective strategy to confront infectious diseases,
among which is leishmaniasis, that threat public health. Despite laborious efforts there is still …

Purpose Madecassic acid (MCA) is a natural triterpenoid isolated from centellae herba that
has diverse biological effects, such as anti-inflammatory, antioxidant, and anticancer …

Background: Nanotechnology has gained enormous attention in pharmaceutical research.
Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100 …

Solubility is a critical factor for the therapeutic action of drugs and does not depend on the
administration of routes. Various conventional methods are used to enhance the solubility of …

(1) Background: 2-Methoxyestradiol (2ME) is a metabolite of estrogens and possesses
promising anti-proliferative and cytotoxic activities. However, it suffers unfavorable …