Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC)
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …

Lipids represent the most abundant molecular type in the brain with a fat content of
approximately 60% of the dry brain weight in humans. Despite this fact, little attention has …

Extracting membrane proteins from the hydrophobic environment of the biological
membrane, in a physiologically relevant and stable state, suitable for downstream analysis …

The cholesterol affinities of many integral plasma membrane proteins have been estimated
by molecular computation. However, these values lack experimental confirmation. We …

Abstract Calcium‐sensing receptor (CaSR), a family CG‐protein‐coupled receptor, plays a
crucial role in regulating calcium homeostasis by sensing small concentration changes of …

Plasma and intracellular membranes are characterized by different lipid compositions that
enable proteins to localize to distinct subcellular compartments [1]. Many proteins interact …

The class C orphan GPCR GPR156, which lacks the typical extracellular region, plays a
pivotal role in auditory function through Gi2/3. Here, we demonstrate that GPR156 with high …

Calmodulin (CaM) is the main calcium (Ca2+) binding protein that transduces the calcium
signal to numerous downstream proteins including Ca2+-CaM dependent protein kinase II …

Metabotropic glutamate receptors (mGluRs) are class CG protein-coupled receptors that
function as obligate dimers in regulating neurotransmission and synaptic plasticity in the …

The cholesterol affinities of many integral plasma membrane proteins have been estimated
by molecular simulation techniques. However, these values lack experimental confirmation …