Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …

Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in
numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of …

Chronic liver diseases represent a global health problem due to their high prevalence
worldwide and the limited available curative treatment options. They can result from various …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it
can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer …

Liver fibrosis affects millions of people worldwide and is rising vastly over the past decades.
With no viable therapies available, liver transplantation is the only curative treatment for …