[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
Updated review of advances in microRNAs and complex diseases: taxonomy, trends and challenges of computational models
Since the problem proposed in late 2000s, microRNA–disease association (MDA)
predictions have been implemented based on the data fusion paradigm. Integrating diverse …
predictions have been implemented based on the data fusion paradigm. Integrating diverse …
[HTML][HTML] A proteogenomic portrait of lung squamous cell carcinoma
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology
Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
[HTML][HTML] Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
X Xiao, M Xu, H Yu, L Wang, X Li, J Rak… - Signal transduction and …, 2021 - nature.com
Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium,
leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes …
leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes …
[HTML][HTML] Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials
Y Zheng, Y Liu, J Yang, L Dong, R Zhang, S Tian… - Nature …, 2024 - nature.com
Abstract Characterization and integration of the genome, epigenome, transcriptome,
proteome and metabolome of different datasets is difficult owing to a lack of ground truth …
proteome and metabolome of different datasets is difficult owing to a lack of ground truth …
The risks of miRNA therapeutics: in a drug target perspective
S Zhang, Z Cheng, Y Wang, T Han - Drug design, development …, 2021 - Taylor & Francis
RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
[HTML][HTML] Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases
Y Liu, W Ding, J Wang, X Ao, J Xue - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality
worldwide and seriously threatens human health and life. Cardiomyocyte death is …
worldwide and seriously threatens human health and life. Cardiomyocyte death is …
lncRNAfunc: a knowledgebase of lncRNA function in human cancer
The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …
physiological processes and their dysfunction can impact diverse human diseases. To date …
The miRNA: a small but powerful RNA for COVID-19
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …