Flavokawain C (FKC) is a naturally occurring chalcone which can be found in Kava (Piper
methysticum Forst) root. The present study evaluated the effect of FKC on the growth of …

The Wittig reaction enables the synthesis of an alkene from the reaction of an aldehyde or
ketone with the ylide generated from a phosphonium salt. Undoubtedly, its usefulness in the …

Background The kava-kava plant (Piper methysticum) is traditionally consumed by the
pacific islanders and has been linked to be involved in several biological activities …

Flavokawain B (FKB) is a naturally occurring chalcone that can be isolated through the root
extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to …

Rationale Kava has been used for centuries by Pacific Islanders for its tranquilizing and
sedative effects. Recent clinical trials suggest that kava has therapeutic value for the …

AIDS and influenza are viral pandemics and remain one of the leading causes of human
deaths worldwide. The increasing resistance of these diseases to synthetic drugs demands …

Diabetes mellitus (DM) is a disease that is caused by a malfunction of carbohydrate
metabolism, which plays an important role in the development of long-term diabetic …

Kava (Piper methysticum), a perennial shrub native to the South Pacific islands, has been
used to relieve anxiety. Recently, several cases of severe hepatotoxicity have been reported …

S phase kinase-associated protein 2 (Skp2) has been shown to be required for spontaneous
tumor development that occurs in the retinoblastoma protein (pRb) deficient mice. Here we …

A novel series of flavokawain B derivatives, chalcone Mannich bases (4–10) were designed,
synthesized, characterized, and evaluated for the inhibition activity against …