The kava chalcone flavokawain B exerts inhibitory activity and synergizes with BCL-2 inhibition in malignant B-cell lymphoma
M Zhao, X Jiang, J Fang, Y Lin, Y Li, R Pei, P Ye, Y Lu… - Phytomedicine, 2023 - Elsevier
Background B-cell lymphoma, which originates from B cells at diverse differentiation stages,
is the most common non-Hodgkin lymphoma with tremendous treatment challenges and …
is the most common non-Hodgkin lymphoma with tremendous treatment challenges and …
Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues
Herein, we describe the total syntheses of three bioactive pyrones isolated from Polygala
sabulosa (ie, 1, 4, and 7) and eight isolated from Piper methysticum (ie, 8–10, 13, 15, and 18 …
sabulosa (ie, 1, 4, and 7) and eight isolated from Piper methysticum (ie, 8–10, 13, 15, and 18 …
Assessment of the efficacy of Piper methysticum (Micrembryeae: Piperaceae) as a bioinsecticide, and/or spinosad combined with attractive plant volatiles for a novel lure and kill …
A Horain, L Leroy, L Pöllabauer, F Mas… - Journal of Economic …, 2024 - academic.oup.com
Abstract The Queensland fruit fly, Bactrocera tryoni (Froggatt)(Diptera: Tephritidae), is a crop
pest of global economic importance because of its wide range of hosts and its invasiveness …
pest of global economic importance because of its wide range of hosts and its invasiveness …
Flavokawain A ameliorates pulmonary fibrosis by inhibiting the TGF-β signaling pathway and CXCL12/CXCR4 axis
T Xiao, D Gao, X Gu, Y Zhang, Y Zhu, Z Zhang… - European Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease characterized by
myofibroblast proliferation and extracellular matrix deposition that has a high mortality rate …
myofibroblast proliferation and extracellular matrix deposition that has a high mortality rate …
[HTML][HTML] Dietary feeding of Flavokawain A, a Kava chalcone, exhibits a satisfactory safety profile and its association with enhancement of phase II enzymes in mice
Flavokawain A (FKA), a major chalcone in the Kava plant, has recently demonstrated
promising anti-cancer activities. A systematic evaluation of FKA's safety profile has not been …
promising anti-cancer activities. A systematic evaluation of FKA's safety profile has not been …
Chemoenzymatic synthesis of enantiomerically enriched kavalactones
A Kamal, T Krishnaji, GBR Khanna - Tetrahedron letters, 2006 - Elsevier
Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl
5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good …
5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good …
In vitro Toxicity and in vivo Immunomodulatory Effects of Flavokawain A and Flavokawain B in Balb/C Mice
N Abu, NE Mohamed, N Tangarajoo… - Natural Product …, 2015 - journals.sagepub.com
Flavokawains are chalcones that can be found in the root extracts of the kava-kava (Piper
methysticum) plant. Flavokawain A and flavokawain B are known to possess potential anti …
methysticum) plant. Flavokawain A and flavokawain B are known to possess potential anti …
A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice
TW Chou, JH Feng, CC Huang, YW Cheng, SC Chien… - PloS one, 2013 - journals.plos.org
Alpinia pricei Hayata is a Formosan plant which has been popularly used as nutraceutical or
folk medicine for inflammation and various disorders. An active compound of the plant …
folk medicine for inflammation and various disorders. An active compound of the plant …
Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression
X Zhao, YL Chao, QB Wan, XM Chen… - Canadian journal of …, 2011 - cdnsciencepub.com
Novel effective drugs are still urgently needed in the prevention and treatment of oral
adenoid cystic carcinoma (ACC). In this study, we have assessed the antitumor potential and …
adenoid cystic carcinoma (ACC). In this study, we have assessed the antitumor potential and …
A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls
The search of alternative compounds to control tropical diseases such as schistosomiasis
has pointed to secondary metabolites derived from natural sources. Piper species are …
has pointed to secondary metabolites derived from natural sources. Piper species are …