Mutations in the epidermal growth factor receptor (EGFR) gene are commonly observed in
non-small-cell lung cancer (NSCLC), particularly in tumors of adenocarcinoma (ADC) …

Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops
this disease. Although previously tobacco‐derived carcinogens and enzyme polymorphisms …

Objective To establish evidence-based recommendations for the molecular analysis of lung
cancers that are that are required to guide EGFR-and ALK-directed therapies, addressing …

Lung cancer is a complex disease composed of diverse histological and molecular types
with clinical relevance. The advent of large-scale molecular profiling has been helpful to …

Lung cancer is the leading cause of cancer-related mortality. While the majority of lung
cancers are associated with tobacco smoke, approximately 10–15% of US lung cancers …

The development and clinical application of inhibitors that target the epidermal growth factor
receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the …

Although most lung cancers are a result of smoking, approximately 25% of lung cancer
cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths …

Abstract c-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which
leads to chronic myelogenous leukemia. The details of this mechanism have been elusive …

A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why
some tumors respond and others do not. The observation that many tumors express EGF …

Purpose: This study evaluated the mutational profile of epidermal growth factor receptor
(EGFR) and KRAS in non–small cell lung cancers in Hong Kong and determined their …