Stroke is a devastating condition that can lead to significant morbidity and mortality. The
aftermath of a stroke, particularly hemorrhagic transformation (HT) and brain edema, can …

Despite significant progress in modern medicine and pharmacology, damage to the nervous
system with various etiologies still poses a challenge to doctors and scientists. Injuries lead …

The systemic inflammatory response following acute ischaemic stroke remains incompletely
understood. We characterised the circulating inflammatory profile in 173 acute ischaemic …

Abstract N6-Methyladenosine (m6A) is a neuronal-enriched, reversible post-transcriptional
modification that regulates RNA metabolism. The m6A-modified RNAs recruit various m6A …

Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Blood–brain barrier (BBB) is comprised of brain microvascular endothelial cells (ECs),
astrocytes, perivascular microglia, pericytes, neuronal processes, and the basal lamina. As a …

Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate
heart tissue is an attractive approach. After myocardial infarction (MI), heart repair proceeds …

Cerebral ischemic damage is prevalent and the second highest cause of death globally
across patient populations; it is as a substantial reason of morbidity and mortality …

Background There is a lack of comprehensive profile assessment on complete blood count
(CBC)-derived systemic-inflammatory indices, and their correlations with clinical outcome in …

Ischemic damage to the brain and loss of neurons contribute to functional disabilities in
many stroke survivors. Recovery of neuroplasticity is critical to restoration of function and …