Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells
M Zhou, Y Feng, X Zhang, J Chen, N Yao, S Fu… - …, 2024 - Taylor & Francis
Approximately two-thirds of hepatocellular carcinoma (HCC) is considered a “cold tumor”
characterized by few tumor-infiltrating T cells and an abundance of immunosuppressive …
characterized by few tumor-infiltrating T cells and an abundance of immunosuppressive …
[HTML][HTML] GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism
R Wang, Q Min, Y Guo, Y Zhou, X Zhang, D Wang… - Iscience, 2024 - cell.com
Prostate cancer (PCa) is a serious health concern for men due to its high incidence and
mortality rate. The first therapy typically adopted is androgen deprivation therapy (ADT) …
mortality rate. The first therapy typically adopted is androgen deprivation therapy (ADT) …
GL-V9 induce apoptosis of CML cells via MAPK signaling pathway.
F Jiang, Y Xue, Q Zhang, T Ma, Y Li, X Yu - Heliyon, 2024 - cell.com
GL-V9, a derivative of wogonin, has shown potent antitumor effects in various cancers, yet its
impact on chronic myeloid leukemia (CML) remains unexplored. In this study, we found that …
impact on chronic myeloid leukemia (CML) remains unexplored. In this study, we found that …
Identification and properties of TRPV4 mutant channels present in polycystic kidney disease patients
AM Hernández-Vega, I Llorente… - Function, 2024 - academic.oup.com
Polycystic kidney disease (PKD), a disease characterized by enlargement of the kidney
through cystic growth is the fourth leading cause of end-stage kidney disease world-wide …
through cystic growth is the fourth leading cause of end-stage kidney disease world-wide …
Integrated pan-cancer genomic analysis reveals the role of SLC30A5 in the proliferation, metastasis, and prognosis of hepatocellular carcinoma
Y Liu, T Lu, R Li, L Cui, R Xu, S Teng, D Baranenko… - Journal of …, 2024 - jcancer.org
Background: SLC30A5, a member of the solute transporter protein family, is implicated in
tumorigenesis and cancer progression. This study aimed to explore the expression and …
tumorigenesis and cancer progression. This study aimed to explore the expression and …
Pharmacokinetics, tissue distribution, and excretion study of GL‐V9 and its glucuronide metabolite 5‐O‐glucuronide GL‐V9 in Sprague–Dawley rats
X Zhang, G Liu, Z Sang, X Jin, Y Wang… - Biomedical …, 2024 - Wiley Online Library
The objective of this study is to explore the pharmacokinetics, tissue distribution, and
excretion patterns of GL‐V9 and its glucuronide metabolite, 5‐O‐glucuronide GL‐V9 …
excretion patterns of GL‐V9 and its glucuronide metabolite, 5‐O‐glucuronide GL‐V9 …