Circulating blood platelets are specialized cells that prevent bleeding and minimize blood
vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are …

Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative
medicine owing to their ability to differentiate into any cell type in the body. After more than …

Human organoid systems recapitulate in vivo organ architecture yet fail to capture complex
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and …

Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell
interactions occurring during organogenesis. Three-dimensional organoids generate …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

The development of iPSCs reflected the merging of three major scientific streams and has in
turn led to additional new branches of investigation. However, there is still debate about …

Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …

Genome editing of human pluripotent stem cells (hPSCs) provides powerful opportunities for
in vitro disease modeling, drug discovery, and personalized stem cell-based therapeutics …

Adoptive immunotherapy with functional T cells is potentially an effective therapeutic
strategy for combating many types of cancer and viral infection. However, exhaustion of …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …