Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

The Trøndelag Health Study (the HUNT Study) is a population-based cohort study of the
adult population in Trøndelag County, Norway. It was previously called the Nord-Trøndelag …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Preeclampsia and gestational hypertension are common pregnancy complications
associated with adverse maternal and child outcomes. Current tools for prediction …

The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic
basis remains largely unresolved. We present a maternal genome-wide meta-analysis of …

Summary The Taiwan Biobank (TWB) is an ongoing prospective study of> 150,000
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …

Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across
the life course; a key benefit over short-term prediction models. To produce risk estimates …

Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target
of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods …

Despite evidence suggesting that insomnia is associated with the risk of dementia and
cognitive dysfunction, studies have shown mixed results. Dementia has a long prodromal …