EGFR is a prototypical receptor tyrosine kinase that is overexpressed in multiple cancers
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …

As a breakthrough strategy for cancer treatment, immunotherapy mainly consists of immune
checkpoint inhibitors (ICIs) and other immunomodulatory drugs that provide a durable …

Purpose: EGFR pathway inhibition may promote anti–programmed cell death protein 1 (PD-
1) responses in preclinical models, but how EGFR inhibition affects tumor antigen …

Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

In the recent years, the prevalence of HPV-positive oropharyngeal squamous cell carcinoma
(OPSCC) has increased significantly. Currently, nearly 80-90% of all oropharynx tumors are …

Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common
cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous …

Receptor tyrosine kinases (RTKs) are cell surface receptors that bind growth factor ligands
and initiate cellular signaling. Of the 20 classes of RTKs, 7 classes, IV, VIII, and X, are linked …

Management of metastatic head and neck squamous cell carcinoma is evolving as new
systemic therapies have led to improvements in survival, and as advances in locoregional …

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

Simple Summary Human papillomavirus (HPV)-positive head and neck squamous cell
carcinoma (HNSCC) represents a distinct entity with molecular, pathological, and clinical …