Immune checkpoint inhibitors (ICI) have achieved unprecedented clinical success in cancer
treatment. However, drug resistance to ICI therapy is a major hurdle that prevents cancer …

Introduction An effective tool is needed to predict the prognosis of head and neck squamous
cell carcinoma (HNSCC). Human papillomavirus (HPV) positive HNSCC patients generally …

Combinational therapy has improved the cancer therapeutic landscape but is associated
with a concomitant increase in adverse side reactions. Emerging evidence proposes that …

Immune checkpoints modulate the immune response and represent important
immunotherapy targets for cancer treatment. However, as many tumors are resistant to …

The mechanism underlying the association between the development of head and neck
squamous cell carcinoma (HNSCC) and ferroptosis is unclear. We analyzed the …

Macrophages are immune cells in the TME that can not only inhibit angiogenesis,
extracellular matrix remodeling, cancer cell proliferation, and metastasis but also mediate …

Simple Summary In recent years, checkpoint inhibitor treatment of tumors has caused a stir.
The response of patients with metastases showed outstanding success for some cancer …

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy over the past
decade. Despite their beneficial effects on treating numerous types of tumors, cardiotoxicity …

Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells associated
with favourable prognosis and response to immunotherapy in cancer, but the immune …

Objectives Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma
(HNSCC) is currently an incurable disease. To improve treatment strategies, combinations of …