Mesenchymal stem cells (MSCs) may influence the growth and metastasis of various human
malignancies, including hepatocellular carcinoma (HCC). Therefore, the underlying …

Background: TGF-β regulates prostate growth by inhibiting epithelial cell proliferation and
inducing apoptosis through eliciting a dynamic signaling pathway. In metastatic prostate …

The so‐called “seed and soil” hypothesis proposed by S tephen P aget in 1889 to explain
the metastatic behavior of cancer cells and the homing of certain cancers to “selected” sites …

Tumors produce several factors, such as Prostaglandins (PGs), Interleukin (IL)-10, Vascular
Endothelial Growth Factor (VEGF) and Transforming Growth Factor (TGF)-β, which may …

Locally produced transforming growth factor-β (TGF-β) promotes tumor-induced
immunosuppression and contributes to resistance to immunotherapy. This article explores …

Virtually all solid tumors are dependent on a vascular network to provide them with the right
amount of nutrients and oxygen. In that sense, low oxygen tension or hypoxia leads to an …

We have examined whether Ad. sTβRFc and TAd. sTβRFc, two oncolytic viruses expressing
soluble transforming growth factor-β receptor II fused with human Fc (sTGFβRIIFc), can be …

Both RAS and transforming growth factor (TGF)-β signaling cascades are central in
tumorigenesis and show synergisms depending on tumor stage and tissue context. In this …

Objective This review describes genetic and molecular changes related to adenocarcinoma
of the esophagus and gastroesophageal junction (GEJ) with emphasis on prognostic value …

Abstract Tranilast (N-[3, 4-dimethoxycinnamonyl]-anthranilic acid) is a drug of low toxicity
that is orally administered, and has been used clinically in Japan as an antiallergic and …