Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

[HTML][HTML] Superoxide anion chemistry—Its role at the core of the innate immunity

CMC Andrés, JM Pérez de la Lastra… - International journal of …, 2023 - mdpi.com
Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

[HTML][HTML] Immunology of aging: the birth of inflammaging

T Fulop, A Larbi, G Pawelec, A Khalil, AA Cohen… - Clinical reviews in …, 2021 - Springer
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

COVID‐19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps

L Borges, TC Pithon-Curi, R Curi… - Mediators of …, 2020 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is a virus‐induced respiratory disease that may
progress to acute respiratory distress syndrome (ARDS) and is triggered by …

[HTML][HTML] Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID-19: a meta-analysis

BM Henry, I Cheruiyot, J Vikse, V Mutua… - Acta Bio Medica …, 2020 - ncbi.nlm.nih.gov
Background: There is a compelling need to identify clinical and laboratory predictors of
unfavorable clinical course and death in patients with coronavirus disease (COVID-19). A …

[HTML][HTML] Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

T Pan, S Sun, Y Chen, R Tian, E Chen, R Tan, X Wang… - Critical Care, 2022 - Springer
Background Effective removal of pathogenic bacteria is key to improving the prognosis of
sepsis. Polymorphonuclear neutrophils (PMNs) are the most important components of innate …

[HTML][HTML] Inflammatory microenvironment of skin wounds

Z Wang, F Qi, H Luo, G Xu, D Wang - Frontiers in immunology, 2022 - frontiersin.org
Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

[HTML][HTML] Neutrophil extracellular traps activate proinflammatory functions of human neutrophils

D Dömer, T Walther, S Möller, M Behnen… - Frontiers in …, 2021 - frontiersin.org
Neutrophil extracellular traps (NETs) consist of decondensed nuclear chromatin that is
associated with proteins and are released by neutrophils during an inflammatory response …

[HTML][HTML] Neutrophil elastase: From mechanisms to therapeutic potential

W Zeng, Y Song, R Wang, R He, T Wang - Journal of Pharmaceutical …, 2023 - Elsevier
Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is
involved in microbicidal activity. NE is an important factor promoting inflammation, has …

[HTML][HTML] Gingiva-derived mesenchymal stem cells: potential application in tissue engineering and regenerative medicine-a comprehensive review

D Kim, AE Lee, Q Xu, Q Zhang, AD Le - Frontiers in Immunology, 2021 - frontiersin.org
A unique subpopulation of mesenchymal stem cells (MSCs) has been isolated and
characterized from human gingival tissues (GMSCs). Similar to MSCs derived from other …