The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

Dengue is one of the most frequently transmitted mosquito-borne diseases in the world,
which creates a significant public health concern globally, especially in tropical and …

Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host
membranes, incorporating both viral and host factors facilitating viral replication. In this …

Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

Mitochondrial antiviral signaling protein (MAVS) functions as a “switch” in the immune signal
transduction against most RNA viruses. Upon viral infection, MAVS forms prion-like …

Summary Type I interferon (IFN-I) signaling is central to inducing antiviral innate immunity.
However, the mechanisms for IFN-I signaling self-regulation are still largely unknown. Here …

Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes,
causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly …

Dengue virus is an important human pathogen, infecting an estimated 400 million
individuals per year and causing symptomatic disease in a subset of approximately 100 …

The prompt and tightly controlled induction of type I interferon is a central event of the
immune defense against viral infection. Flaviviruses comprise a large family of arthropod …

Ubiquitination is an essential mechanism in the control of antiviral immunity upon virus
infection. Here, we identify a series of ubiquitination-modulating enzymes that are …