[HTML][HTML] Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
J Yuan, J Yu, Y Huang, Z He, J Luo, Y Wu, Y Zheng… - BMC medicine, 2020 - Springer
Background Zika virus (ZIKV) infection is a global health problem, and its complications,
including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued …
including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued …
[HTML][HTML] How dengue virus circumvents innate immunity
In the battle between a virus and its host, innate immunity serves as the first line of defense
protecting the host against pathogens. The antiviral actions start with the recognition of …
protecting the host against pathogens. The antiviral actions start with the recognition of …
[HTML][HTML] Host immune response against DENV and ZIKV infections
SD Sekaran, AA Ismail, G Thergarajan… - Frontiers in cellular …, 2022 - frontiersin.org
Dengue is a major public health concern, affecting almost 400 million people worldwide,
with about 70% of the global burden of disease in Asia. Despite revised clinical …
with about 70% of the global burden of disease in Asia. Despite revised clinical …
[HTML][HTML] Viral infection modulates mitochondrial function
X Li, K Wu, S Zeng, F Zhao, J Fan, Z Li, L Yi… - International Journal of …, 2021 - mdpi.com
Mitochondria are important organelles involved in metabolism and programmed cell death
in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity …
in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity …
[HTML][HTML] Zika virus antagonizes interferon response in patients and disrupts RIG-I–MAVS interaction through its CARD-TM domains
Y Hu, X Dong, Z He, Y Wu, S Zhang, J Lin, Y Yang… - Cell & bioscience, 2019 - Springer
Background The emerging threat to global health associated with the Zika virus (ZIKV)
epidemics and its link to severe complications highlights a growing need to better …
epidemics and its link to severe complications highlights a growing need to better …
Tembusu virus nonstructural protein 2B antagonizes type I interferon production by targeting MAVS for degradation
P Zhou, Y Li, A Liu, Q Zhang, W Wu, H Jin… - Journal of …, 2022 - Am Soc Microbiol
Tembusu virus (TMUV) is a newly emerged avian flavivirus that has caused severe egg-drop
syndrome and fatal encephalitis in domestic ducks. It has spread widely throughout the main …
syndrome and fatal encephalitis in domestic ducks. It has spread widely throughout the main …
Molecular mechanisms in the pathogenesis of dengue infections
GN Malavige, GS Ogg - Trends in Molecular Medicine, 2024 - cell.com
Dengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and
disease incidence are rising markedly, leading to healthcare systems being overwhelmed …
disease incidence are rising markedly, leading to healthcare systems being overwhelmed …
Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo
X Qian, B Wu, H Tang, Z Luo, Z Xu… - Emerging microbes & …, 2022 - Taylor & Francis
Yellow fever virus (YFV) infection is a major public concern that threatens a large population
in South America and Africa. No specific anti-YFV drugs are available till now. Here, we …
in South America and Africa. No specific anti-YFV drugs are available till now. Here, we …
[HTML][HTML] The role of mitochondria in the pathogenesis of Kawasaki disease
MA Beckley, S Shrestha, KK Singh… - Frontiers in …, 2022 - frontiersin.org
Kawasaki disease is a systemic vasculitis, especially of the coronary arteries, affecting
children. Despite extensive research, much is still unknown about the principal driver behind …
children. Despite extensive research, much is still unknown about the principal driver behind …
[HTML][HTML] RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production
JK Sprokholt, TM Kaptein, JL van Hamme… - PLoS …, 2017 - journals.plos.org
Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated
responses critical for immunity against viral infections and effective vaccines. However, it is …
responses critical for immunity against viral infections and effective vaccines. However, it is …