A growing body of evidence has demonstrated the role of components of innate immunity,
including Toll-like receptors (TLRs), the retinoic acid-inducible gene I/melanoma …

Early sensing of viral components or infection-induced tissue damage is a prerequisite for
the successful control of pathogenic viruses by the host innate immune system. Recent …

The Flaviviridae family comprises a number of human pathogens, which, although sharing
structural and functional features, cause diseases with very different outcomes. This can be …

With 40% of the world population at risk, infections with dengue virus (DENV) constitute a
serious threat to public health. While there is no antiviral therapy available against this …

The potential health risks associated with (re-) emerging positive-strand RNA (+ RNA)
viruses emphasizes the need for understanding host-pathogen interactions for these …

Background Vector-borne flaviviruses, including tick-borne encephalitis virus (TBEV), Zika
virus (ZIKV), West Nile virus (WNV), yellow fever virus (YFV), dengue virus (DENV), and …

Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To
counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists …

Mosquito-borne flaviviruses include many viruses that are important human pathogens,
including Yellow fever virus, Dengue virus, Zika virus and West Nile virus. While these …

Senecavirus A (SVA) is an oncolytic virus, which can propagate in human tumor cells and
has been used as an oncolytic virotherapy candidate in humans. Besides, SVA circulates in …

Dengue virus is a positive sense, single-stranded RNA virus of the Flaviviridae family that
causes mild to severe dengue fever in hundreds of millions of people in tropical/subtropical …