Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

Viruses evade the innate immune response by suppressing the production or activity of
cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Ribosome-associated quality control (RQC) pathways protect cells from toxicity caused by
incomplete protein products resulting from translation of damaged or problematic mRNAs …

RNA-binding proteins (RBPs) facilitate post-transcriptional control of eukaryotic gene
expression at multiple levels. The RBP tristetraprolin (TTP/Zfp36) is a signal-induced …

During protein synthesis, translating ribosomes encounter many challenges imposed by
various types of defective mRNAs that can lead to reduced cellular fitness and, in some …

RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …

MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by
inhibiting translation initiation and by destabilizing target mRNAs. The CCR4–NOT complex …

Translation of messenger RNAs (mRNAs) with premature termination codons produces
truncated proteins with potentially deleterious effects. This is prevented by nonsense …