Venomous animals have evolved a vast array of peptide toxins for prey capture and
defence. These peptides are directed against a wide variety of pharmacological targets …

By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal
conduction, disturbances of which increase risk of atrial fibrillation. We report a meta …

Electrocardiographic measures are indicative of the function of the cardiac conduction
system. To search for sequence variants that modulate heart rate, PR interval and QRS …

During the last two decades, the number of sequence-known proteins has increased rapidly.
In contrast, the corresponding increment for structure-known proteins is much slower. The …

Sodium channel blockers are approved for intravenous administration in the treatment of
neuropathic pain states. Preclinical studies have suggested antihyperalgesic effects on the …

Voltage-gated Na+ channels play important functional roles in the generation of electrical
excitability in most vertebrate and invertebrate species. These channels are members of a …

Rationale: Although the sodium channel locus SCN10A has been implicated by genome-
wide association studies as a modulator of cardiac electrophysiology, the role of its gene …

Background—Brugada syndrome is a form of idiopathic ventricular fibrillation characterized
by a right bundle-branch block pattern and ST elevation (STE) in the right precordial leads of …

Background Atrial fibrillation (AF) is a common arrhythmia seen in clinical practice.
Occasionally, no common risk factors are present in patients with this arrhythmia. This …