[HTML][HTML] Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: a scientific review
JS Petrick, B Brower-Toland, AL Jackson… - Regulatory Toxicology …, 2013 - Elsevier
Gene expression can be modulated in plants to produce desired traits through agricultural
biotechnology. Currently, biotechnology-derived crops are compared to their conventional …
biotechnology. Currently, biotechnology-derived crops are compared to their conventional …
Evolving gene expression: from G to E to G× E
A Hodgins-Davis, JP Townsend - Trends in Ecology & Evolution, 2009 - cell.com
Analyses of gene expression data sets for multiple individuals and species promise to shed
light on the mode of evolution of gene expression. However, complementary complexities …
light on the mode of evolution of gene expression. However, complementary complexities …
Lack of detectable oral bioavailability of plant microRNAs after feeding in mice
B Dickinson, Y Zhang, JS Petrick, G Heck… - Nature …, 2013 - nature.com
(Supplementary Fig. 5). Sequencing of the mouse-rice RNA library at a depth of just 5 million
reads readily obtained the 30 most abundant miRNAs found in deep sequencing of rice …
reads readily obtained the 30 most abundant miRNAs found in deep sequencing of rice …
A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49
MR Van Gilst, H Hadjivassiliou… - Proceedings of the …, 2005 - National Acad Sciences
Appropriate response to nutritional stress is critical for animal survival and metabolic health.
To better understand regulatory networks that sense and respond to nutritional availability …
To better understand regulatory networks that sense and respond to nutritional availability …
Obesity: considerations about etiology, metabolism, and the use of experimental models
LO Pereira-Lancha, PL Campos-Ferraz… - … syndrome and obesity …, 2012 - Taylor & Francis
Studies have been conducted in order to identify the main factors that contribute to the
development of obesity. The role of genetics has also been extensively studied. However …
development of obesity. The role of genetics has also been extensively studied. However …
[HTML][HTML] Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats
KH Collins, RA Reimer, RA Seerattan… - Osteoarthritis and …, 2015 - Elsevier
Osteoarthritis (OA) in obese individuals is often attributed to joint loading. However, a
subtype of OA, Metabolic OA, may be due to obesity-related intrinsic factors but remains to …
subtype of OA, Metabolic OA, may be due to obesity-related intrinsic factors but remains to …
The inflammatory profile and liver damage of a sucrose-rich diet in mice
LSC Oliveira, DA Santos, S Barbosa-da-Silva… - The Journal of nutritional …, 2014 - Elsevier
It is still unclear if an isoenergetic, sucrose-rich diet leads to health consequences. Aims To
investigate the effects of excessive sucrose within an isoenergetic diet on metabolic …
investigate the effects of excessive sucrose within an isoenergetic diet on metabolic …
Reply to Lack of detectable oral bioavailability of plant microRNAs after feeding in mice
We agree with Dickinson et al. 1 that follow-up studies to carefully evaluate the uptake of
food-derived microRNAs (miRNAs) and the potential of crosskingdom gene regulation in …
food-derived microRNAs (miRNAs) and the potential of crosskingdom gene regulation in …
High-carbohydrate diet selectively induces tumor necrosis factor-α production in mice liver
AVM Ferreira, ÉG Mario, LCJ Porto, SP Andrade… - Inflammation, 2011 - Springer
Obesity may represent a state of chronic low-grade inflammation associated with infiltration
of adipose tissue by inflammatory cells. Tumor necrosis factor-α (TNF-α) and monocyte …
of adipose tissue by inflammatory cells. Tumor necrosis factor-α (TNF-α) and monocyte …
[HTML][HTML] A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice
JS Petrick, WM Moore, WF Heydens, MS Koch… - Regulatory Toxicology …, 2015 - Elsevier
New biotechnology-derived crop traits have been developed utilizing the natural process of
RNA interference (RNAi). However, plant-produced double stranded RNAs (dsRNAs) are …
RNA interference (RNAi). However, plant-produced double stranded RNAs (dsRNAs) are …