[HTML][HTML] The PI3K/AKT pathway—The potential key mechanisms of traditional Chinese medicine for stroke

C Gu, Q Zhang, Y Li, R Li, J Feng, W Chen… - Frontiers in …, 2022 - frontiersin.org
Stroke is associated with a high disability and fatality rate, and adversely affects the quality
of life of patients and their families. Traditional Chinese Medicine (TCM) has been used …

[HTML][HTML] Nerve regeneration using decellularized tissues: challenges and opportunities

M Mahdian, TS Tabatabai, Z Abpeikar… - Frontiers in …, 2023 - frontiersin.org
In tissue engineering, the decellularization of organs and tissues as a biological scaffold
plays a critical role in the repair of neurodegenerative diseases. Various protocols for cell …

[HTML][HTML] Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

Y Rong, Z Wang, P Tang, J Wang, C Ji, J Chang… - Bioactive Materials, 2023 - Elsevier
Spinal cord injury (SCI) is a severe disease of the nervous system that causes irreparable
damage and loss of function, for which no effective treatments are available to date …

Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after …

Y Xie, Y Sun, Y Liu, J Zhao, Q Liu, J Xu, Y Qin, R He… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) disrupts the blood–spinal cord barrier (BSCB), potentially
exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity …

[HTML][HTML] Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke

ZH Zhu, F Jia, W Ahmed, GL Zhang… - Neural Regeneration …, 2023 - journals.lww.com
Our previous study demonstrated the potential therapeutic role of human neural stem cell-
derived exosomes (hNSC-Exo) in ischemic stroke. Here, we loaded brain-derived …

[HTML][HTML] Microglia-derived exosomal microRNA-151-3p enhances functional healing after spinal cord injury by attenuating neuronal apoptosis via regulating the p53 …

C Li, T Qin, Y Liu, H Wen, J Zhao, Z Luo… - Frontiers in cell and …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a catastrophic event mainly involving neuronal apoptosis and
axonal disruption, and it causes severe motor and sensory deficits. Due to the complicated …

[HTML][HTML] Bone marrow mesenchymal stem cell-derived exosomes accelerate functional recovery after spinal cord injury by promoting the phagocytosis of …

X Sheng, J Zhao, M Li, Y Xu, Y Zhou, J Xu… - Frontiers in Cell and …, 2021 - frontiersin.org
Macrophage phagocytosis contributes predominantly to processing central nervous system
(CNS) debris and further facilitates neurological function restoration after CNS injury. The …

Human placental mesenchymal stem cell-derived exosomes in combination with hyperbaric oxygen synergistically promote recovery after spinal cord injury in rats

H Cheshmi, H Mohammadi, M Akbari, D Nasiry… - Neurotoxicity …, 2023 - Springer
Spinal cord injury (SCI) is a critical medical condition during which sensorimotor function is
lost. Current treatments are still unable to effectively improve these conditions, so it is …

[HTML][HTML] The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases

A Iranpanah, L Kooshki, SZ Moradi, L Saso, S Fakhri… - Pharmaceutics, 2023 - mdpi.com
As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

[HTML][HTML] Clinical trials targeting secondary damage after traumatic spinal cord injury

ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …