Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

Worldwide, hypertension is the leading risk factor for cardiovascular disease and death. An
estimated 122 million people, per the American Heart Association in 2023, have been …

The development of an efficient and straightforward method for cyanation of alcohols is of
great value. However, the cyanation of alcohols always requires toxic cyanide sources …

Binding by the drug imipramine to the protein human serum albumin (HSA) was studied by
using high-performance affinity chromatography. The association equilibrium constants and …

Drug-induced cardiotoxicity is a significant contributor to drug recalls, primarily attributed to
limitations in existing drug screening platforms. Traditional heart-on-a-chip platforms often …

The binding of verapamil to the protein human serum albumin (HSA) was examined by
using high-performance affinity chromatography. Many previous reports have investigated …

We hereby report the ortho-cyanomethylation of aryl fluoroalkyl sulfoxides with acetonitrile
through a sulfonium–Claisen-type rearrangement. This reaction enables the incorporation of …

Aim The aim of the present study was to develop nanoproliposomes of lercanidipine, in
order to overcome its poor biopharmaceutical properties and to improve its therapeutic …

Enantiomerically enriched α, α‐disubstituted phenylacetonitriles have been readily prepared
by stereoselective quaternization of 2‐alkyl‐2‐[2‐(p‐tolylsulfinyl) phenyl] acetonitriles with …

A concise and direct cyanation of secondary and tertiary benzylic and allylic alcohols
catalyzed by Brønsted acid has been developed using trimethylsilyl cyanide (TMSCN) as a …