Publisher Summary This chapter discusses the physiological role of adenosine in the central
nervous system (CNS). In particular, the chapter's attention is directed to the actions of …

Neurotransmitter release and the role of adenosine in its regulation has been investigated
for more than twenty years, and it is now widely accepted that adenosine tonically inhibits …

Dose-response curves for the first interaction of a chemical with a biochemical target
molecule are usually monotonic; ie, they increase or decrease over the entire dose range …

Dorsal root ganglion neurones from 2‐day‐old rats were grown in dissociated culture. The
effect of the adenosine analogue 2‐chloroadenosine (2‐CA) was investigated on action …

Methods Male Sprague-Dawley rats weighing between 150 and 200 g obtained from Sasco
(Omaha, NE) were decapitated, and the hippocampus was dissected free of surrounding …

Adenosine and several of its analogues produced a concentration‐dependent shortening of
calcium‐dependent action potential (cap) duration of mouse dorsal root ganglion (drg) …

The inhibitory neuromodulator adenosine is an endogenous anticonvulsant that terminates
brief seizures in the brain and it has been proposed that loss of adenosine or adenosine …

Spontaneous miniature excitatory postsynaptic currents (MEPSCs) were recorded by whole-
cell voltage-clamp techniques in cultured rat hippocampal pyramidal neurons. The specific …

The intradermal injection of adenosine produces a dose-dependent decrease in mechanical
nociceptive threshold in the hindpaw of the rat that is not attenuated by elimination of indirect …

Receptors for neurotransmitters on astrocytes in the mammalian central nervous system -
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