The integration of a viral genome into the host genome has a major impact on the trajectory
of the infected cell. Integration location and variation within the associated viral genome can …

Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL)
in 5% of infected people with a decades-long latency. Charles RM Bangham reviews the …

The human retroviruses HTLV-1 (human T cell leukemia virus type 1) and HIV-1 persist in
vivo as a reservoir of latently infected T cell clones. It is poorly understood what determines …

Adult T cell leukemia-lymphoma (ATL) is an aggressive malignancy secondary to chronic
infection with the human T cell leukemia virus type I (HTLV-I) retrovirus. ATL carries a dismal …

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

PDZ and LIM domains-containing proteins play pivotal functions in cell cytoskeleton
organization, cell polarization and differentiation. As a key member of the family, PDLIM2 …

Damage to our genomes triggers cellular senescence characterised by stable cell cycle
arrest and a pro-inflammatory secretome that prevents the unrestricted growth of cells with …

HTLV-1 is a global infection with 5-20 million infected individuals. Although only a minority of
infected individuals develop myelopathy, lymphoproliferative malignancy, or inflammatory …

The lung is one of several organs that can be affected by HTLV-1 mediated inflammation.
Pulmonary inflammation associated with HTLV-1 infection involves the interstitium, airways …

Human T-cell lymphotropic virus type 1 (HTLV-1) is the first identified human retrovirus
responsible for two significant diseases: HTLV-1-associated myelopathy/tropical spastic …