Adult T-cell leukemia/lymphoma is an aggressive T-cell malignancy caused by the long-term
infection of human T-cell lymphotropic virus type 1 (HTLV-1). Our understanding of clinical …

Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of
pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 …

Background Human T-lymphotropic virus type 1 (HTLV-1)–associated myelopathy (HAM) is
an inflammatory condition characterized by severe disability and high levels of infected …

The goal of this study was to analyze the genetic expression of antiretroviral restriction
factors (ARF) and acute phase proteins (APP), as well as their correlation with proviral and …

Manipulation of immune cell functions, independently of direct infection of these cells,
emerges as a key process in viral pathophysiology. Chronic infection by Human T-cell …

Objective We evaluated changes of HTLV-1 proviral loads (PVLs) during treatment for
rheumatoid arthritis (RA) and investigated whether these changes affect the clinical course …

Retroviral infections create a large population of cells, each defined by a unique proviral
insertion site. Methods based on short-read high throughput sequencing can identify …

Human T-cell leukemia virus type 1 (HTLV-1) has the potential to transform primary CD4+ T
cells in vitro within a short time; however, the majority of infected individuals maintain an …

O Vírus Linfotrópico de Células T do adulto 1 (HTLV-1) é um retrovírus humano
sexualmente transmissível que apresenta tropismo preferencial por células T CD4+ …

Adult T cell leukemia/lymphoma (ATL) can be susceptible, at least transiently, to treatments
with azidothymidine (AZT) plus IFNα and/or arsenic trioxide. However, the real role of AZT in …