Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning

JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …

Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury

SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates skin photoaging

S Hu, Z Li, J Cores, K Huang, T Su, PU Dinh… - ACS nano, 2019 - ACS Publications
Human dermal fibroblasts (HDFs), the main cell population of the dermis, gradually lose
their ability to produce collagen and renew intercellular matrix with aging. One clinical …

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

B Antebi, LA Rodriguez, KP Walker, AM Asher… - Stem Cell Research & …, 2018 - Springer
Background In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O 2) that is thought
to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under …

Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage

S Zhang, L Jiang, H Hu, H Wang, X Wang, J Jiang… - Life sciences, 2020 - Elsevier
Aims The management of acute liver failure (ALF) is a major challenge worldwide. The
current study aimed to determine the therapeutic potential of TNF-α pretreatment of umbilical …

Molecular mechanisms responsible for anti-inflammatory and immunosuppressive effects of mesenchymal stem cell-derived factors

CR Harrell, MG Jankovic, C Fellabaum… - Tissue engineering and …, 2019 - Springer
Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …

Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy

R Schäfer, G Spohn, PC Baer - Transfusion Medicine and Hemotherapy, 2016 - karger.com
Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …

[HTML][HTML] Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use

V Miceli, G Zito, M Bulati, A Gallo, R Busà… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and
have therefore been extensively investigated in preclinical studies of regenerative medicine …

Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the …

B Liu, F Ding, D Hu, Y Zhou, C Long, L Shen… - Stem cell research & …, 2018 - Springer
Background Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and
release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition …