Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications
WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …
because of their high immunomodulation ability, tropism towards inflamed and injured …
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …
that have been isolated from a variety of tissues, and possess multipotent differentiation …
Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury
SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …
Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates skin photoaging
Human dermal fibroblasts (HDFs), the main cell population of the dermis, gradually lose
their ability to produce collagen and renew intercellular matrix with aging. One clinical …
their ability to produce collagen and renew intercellular matrix with aging. One clinical …
Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
B Antebi, LA Rodriguez, KP Walker, AM Asher… - Stem Cell Research & …, 2018 - Springer
Background In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O 2) that is thought
to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under …
to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under …
Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage
S Zhang, L Jiang, H Hu, H Wang, X Wang, J Jiang… - Life sciences, 2020 - Elsevier
Aims The management of acute liver failure (ALF) is a major challenge worldwide. The
current study aimed to determine the therapeutic potential of TNF-α pretreatment of umbilical …
current study aimed to determine the therapeutic potential of TNF-α pretreatment of umbilical …
Molecular mechanisms responsible for anti-inflammatory and immunosuppressive effects of mesenchymal stem cell-derived factors
CR Harrell, MG Jankovic, C Fellabaum… - Tissue engineering and …, 2019 - Springer
Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …
Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy
R Schäfer, G Spohn, PC Baer - Transfusion Medicine and Hemotherapy, 2016 - karger.com
Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …
[HTML][HTML] Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and
have therefore been extensively investigated in preclinical studies of regenerative medicine …
have therefore been extensively investigated in preclinical studies of regenerative medicine …
Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the …
B Liu, F Ding, D Hu, Y Zhou, C Long, L Shen… - Stem cell research & …, 2018 - Springer
Background Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and
release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition …
release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition …