Therapeutic potential of α7 nicotinic acetylcholine receptors

D Bertrand, CHL Lee, D Flood, F Marger… - Pharmacological …, 2015 - ASPET
Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

[HTML][HTML] Translational implications of CHRFAM7A, an elusive human-restricted fusion gene

I Ihnatovych, RA Saddler, N Sule, K Szigeti - Molecular Psychiatry, 2024 - nature.com
Genes restricted to humans may contribute to human-specific traits and provide a different
context for diseases. CHRFAM7A is a uniquely human fusion gene and a negative regulator …

Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory …

S Zi, JH Li, L Liu, C Deng, X Ao, D Chen… - International …, 2019 - Elsevier
Background Uncontrolled inflammatory responses exacerbate the pathogenesis of septic
acute liver injury (ALI), posing a lethal threat to the host. Dexmedetomidine (DEX) has been …

Varenicline and adverse cardiovascular events: a systematic review and meta‐analysis of randomized controlled trials

LH Sterling, SB Windle, KB Filion, L Touma… - Journal of the …, 2016 - Am Heart Assoc
Background Varenicline is an efficacious smoking‐cessation drug. However, previous meta‐
analyses provide conflicting results regarding its cardiovascular safety. The publication of …

[HTML][HTML] Cholinergic modulation of the immune system–A novel therapeutic target for myocardial inflammation

J Lu, W Wu - International Immunopharmacology, 2021 - Elsevier
The immune system and the nervous system depend on each other for their fine tuning and
working, thus cooperating to maintain physiological homeostasis and prevent infections. The …

[HTML][HTML] Nonlinear analysis of heart rhythm in preeclampsia: a route for translational clinical applications in neuroinflammation

JJ Reyes-Lagos, EA Abarca-Castro - Clinical Hypertension, 2021 - Springer
Preeclampsia is a pregnancy-specific condition which gets detected through hypertension
and excessive protein excretion in urine. While preeclampsia used to be regarded as a self …

Which heart rate variability index is an independent predictor of mortality in cirrhosis?

AS Bhogal, M De Rui, D Pavanello, I El-Azizi… - Digestive and Liver …, 2019 - Elsevier
Background Liver cirrhosis is associated with reduced heart rate variability (HRV), which
indicates impaired integrity of cardiovascular control in this patient population. There are …

Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats

JJ Reyes-Lagos, M Hadamitzky, MA Pena-Castillo… - Physiology & …, 2016 - Elsevier
Besides the well-known roles of oxytocin on birth, maternal bonding, and lactation, recent
evidence shows that this hypothalamic hormone possesses cardioprotective, anti …

[HTML][HTML] Mediation of Cardiac Macrophage Activity via Auricular Vagal Nerve Stimulation Ameliorates Cardiac Ischemia/Reperfusion Injury

CH Chung, B Bretherton, S Zainalabidin… - Frontiers in …, 2020 - frontiersin.org
Background Myocardial infarction (MI) reperfusion therapy causes paradoxical cardiac
complications. Following restoration of blood flow to infarcted regions, a multitude of …

The mechanistic and prognostic implications of heart rate variability analysis in patients with cirrhosis

NUH Abid, AR Mani - Physiological Reports, 2022 - Wiley Online Library
Chronic liver damage leads to scarring of the liver tissue and ultimately a systemic illness
known as cirrhosis. Patients with cirrhosis exhibit multi‐organ dysfunction and high mortality …