[HTML][HTML] Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
concern and the attention of regulatory agencies. These carcinogens—widely detectable in …
[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
Enzyme promiscuity in natural environments: alkaline phosphatase in the ocean
A Srivastava, DEM Saavedra, B Thomson… - The ISME …, 2021 - academic.oup.com
Alkaline phosphatase (APase) is one of the marine enzymes used by oceanic microbes to
obtain inorganic phosphorus (Pi) from dissolved organic phosphorus to overcome P …
obtain inorganic phosphorus (Pi) from dissolved organic phosphorus to overcome P …
[HTML][HTML] Recent studies on DNA adducts resulting from human exposure to tobacco smoke
B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …
smokers and are proposed as being potential biomarkers of cancer risk. We have …
Conformation-dependent lesion bypass of bulky arylamine-dG adducts generated from 2-nitrofluorene in epigenetic sequence contexts
Sequence context influences structural characteristics and repair of DNA adducts, but there
is limited information on how epigenetic modulation affects conformational heterogeneity …
is limited information on how epigenetic modulation affects conformational heterogeneity …
The complexity and regulation of repair of alkylation damage to nucleic acids
N Tsao, OD Schärer… - Critical reviews in …, 2021 - Taylor & Francis
DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The
discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined …
discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined …
Reduction of interstrand charge repulsion of DNA duplexes by salts and by neutral phosphotriesters–contrary effects for harnessing duplex formation
To exploit the formation of DNA duplexes, the charge repulsion between complementary
DNA strands can be reduced by adding salts or by replacing the negatively charged natural …
DNA strands can be reduced by adding salts or by replacing the negatively charged natural …
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine
The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
[HTML][HTML] Size-and stereochemistry-dependent transcriptional bypass of DNA alkyl phosphotriester adducts in mammalian cells
Environmental, endogenous and therapeutic alkylating agents can react with internucleotide
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …
phosphate groups in DNA to yield alkyl phosphotriester (PTE) adducts. Alkyl-PTEs are …
Replication Studies of Alkyl Phosphotriester Lesions in Human Cells
Alkyl phosphotriester (alkyl-PTE) lesions in DNA are shown to be poorly repaired; however,
little is known about how these lesions impact DNA replication in human cells. Here, we …
little is known about how these lesions impact DNA replication in human cells. Here, we …