Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has
progressed dramatically. The key advances include (1) identification of p38 MAP kinase …

Exercise-induced asthma, as recognized in asthmatic subjects, is an exaggerated airway
response to airway dehydration in the presence of inflammatory cells and their mediators …

Epidemiologic reports by CA Pope III et. al. demonstrated that in the Utah Valley, closure of
an open-hearth steel mill over the winter of 1987 was associated with reductions in …

Nuclear factor of activated T cells 5 (NFAT5) is the most recently described member of the
Rel family of transcription factors, including NF-κB and NFAT1-4, which play central roles in …

Publisher Summary This chapter discusses that the network of immune and inflammatory
responses is comprised of a variety of cell types. Coordination of this network occurs through …

A chronic inflammatory disorder of the respiratory airways, asthma is characterized by
bronchial airway inflammation resulting in increased mucus production and airway hyper …

Transient airway narrowing can occur during or following exercise, a phenomenon called
exercise-induced bronchoconstriction (EIB). The main mechanism of EIB is considered to be …

Controversy remains about the causative mediators in the bronchoconstrictive response to
exercise in asthma. This study examined whether mast cell activation is a feature of exercise …

The changes in airway osmolarity have been described to contribute to the production of
exercise-induced bronchoconstriction (EIB) and the development of the late-phase response …

Background Inflammatory cells are increased in the airways of endurance athletes, but their
role in causing exercise‐induced respiratory symptoms and bronchoconstriction, or their …