Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …
Cerebral microvascular pathology in ageing and neurodegeneration
WR Brown and CR Thore (2011) Neuropathology and Applied Neurobiology37, 56–74
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …
Olfaction in Parkinson's disease and related disorders
RL Doty - Neurobiology of disease, 2012 - Elsevier
Olfactory dysfunction is an early 'pre-clinical'sign of Parkinson's disease (PD). The present
review is a comprehensive and up-to-date assessment of such dysfunction in PD and …
review is a comprehensive and up-to-date assessment of such dysfunction in PD and …
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
A Taly, PJ Corringer, D Guedin, P Lestage… - Nature reviews Drug …, 2009 - nature.com
Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …
Small-Conductance Ca2+-Activated K+ Channels: Form and Function
JP Adelman, J Maylie, P Sah - Annual review of physiology, 2012 - annualreviews.org
Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …
throughout the central nervous system. These channels are activated solely by increases in …
Acetylcholinesterase inhibitors from plants
PK Mukherjee, V Kumar, M Mal, PJ Houghton - Phytomedicine, 2007 - Elsevier
Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine,
is considered as a promising strategy for the treatment of neurological disorders such as …
is considered as a promising strategy for the treatment of neurological disorders such as …
The roles of catechins in regulation of systemic inflammation
JM Kim, HJ Heo - Food science and biotechnology, 2022 - Springer
Catechins are a phytochemical present in plants such as tea leaves, beans, black grapes,
cherries, and cacao, and have various physiological activities. It is reported that catechins …
cherries, and cacao, and have various physiological activities. It is reported that catechins …
Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies
DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …
characterized by progressive impairment in cognitive function during mid-to late-adult life …
A label-free fluorescence biosensor based on a bifunctional MIL-101 (Fe) nanozyme for sensitive detection of choline and acetylcholine at nanomolar level
J Guo, S Wu, Y Wang, M Zhao - Sensors and Actuators B: Chemical, 2020 - Elsevier
A label-free and high sensitive fluorescence biosensor for the detection of choline and
acetylcholine (ACh) was developed based on the MIL-101 (Fe) nanozyme with dual …
acetylcholine (ACh) was developed based on the MIL-101 (Fe) nanozyme with dual …