Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

Cerebral microvascular pathology in ageing and neurodegeneration

WR Brown, CR Thore - Neuropathology and applied …, 2011 - Wiley Online Library
WR Brown and CR Thore (2011) Neuropathology and Applied Neurobiology37, 56–74
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …

Olfaction in Parkinson's disease and related disorders

RL Doty - Neurobiology of disease, 2012 - Elsevier
Olfactory dysfunction is an early 'pre-clinical'sign of Parkinson's disease (PD). The present
review is a comprehensive and up-to-date assessment of such dysfunction in PD and …

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

A Taly, PJ Corringer, D Guedin, P Lestage… - Nature reviews Drug …, 2009 - nature.com
Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

JP Adelman, J Maylie, P Sah - Annual review of physiology, 2012 - annualreviews.org
Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

Acetylcholinesterase inhibitors from plants

PK Mukherjee, V Kumar, M Mal, PJ Houghton - Phytomedicine, 2007 - Elsevier
Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine,
is considered as a promising strategy for the treatment of neurological disorders such as …

The roles of catechins in regulation of systemic inflammation

JM Kim, HJ Heo - Food science and biotechnology, 2022 - Springer
Catechins are a phytochemical present in plants such as tea leaves, beans, black grapes,
cherries, and cacao, and have various physiological activities. It is reported that catechins …

Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

A label-free fluorescence biosensor based on a bifunctional MIL-101 (Fe) nanozyme for sensitive detection of choline and acetylcholine at nanomolar level

J Guo, S Wu, Y Wang, M Zhao - Sensors and Actuators B: Chemical, 2020 - Elsevier
A label-free and high sensitive fluorescence biosensor for the detection of choline and
acetylcholine (ACh) was developed based on the MIL-101 (Fe) nanozyme with dual …