Inhibition plays a crucial role in many functional domains, such as cognition, emotion, and
actions. Studies on cognitive aging demonstrate changes in inhibitory mechanisms are age …

Neuronal plastic rearrangements during the development and functioning of neurons are
largely regulated by trophic factors, including nerve growth factor (NGF). NGF is also …

Because of their high energetic demand, neurons within the mammalian central nervous
system are extremely sensitive to changes in partial pressure of oxygen. Faced with acute …

Policosanol (PC) is a mixture of long-chain fatty alcohols that exhibits multiple biological
activities, such as reducing blood lipid and cholesterol levels, lowering blood pressure, and …

Estrogen maintains normal function of basal forebrain (BF) cholinergic neurons and
estrogen replacement therapy (ERT) has therefore been proposed as a therapy for …

There remains an urgent need for therapeutic agents that provide improved symptomatic
treatment and attenuate disease progression in patients with Alzheimer's disease (AD). 5 …

The involvement of an impaired cholinergic neurotransmission in the pathophysiology of
cognitive impairment occurring in vascular dementia (VaD), as well as the possibility of …

Neurofibrillar tangles made up of 'paired helical filaments'(PHFs) consisting of
hyperphosphorylated microtubuleassociated protein tau are major hallmarks of Alzheimer's …

In previous studies we have shown in Alzheimer's disease (AD) an enhanced nuclear
estrogen receptor (ER) α expression in the cholinergic basal forebrain nuclei, ie the vertical …

Brain oxidative stress due to chronic cerebral hypoperfusion was considered to be the major
risk factor in the pathogenesis of vascular dementia. In this study, we investigated the …