Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

The cholinergic system is thought to play an important role in hippocampal-dependent
learning and memory. However, the mechanism of action of the cholinergic system in these …

Recently, neuropathological studies have shown an important motor cortex involvement in
Alzheimer's disease (AD), even in its early stages, despite the lack of clinically evident motor …

Type 2 diabetes is associated with an increased risk of cognitive dysfunction. These effects
seem particularly true for memory functions. This article examines how diabetes and the …

In the symptomatic treatment of mild to moderately severe dementia associated with
Alzheimer's disease, donepezil (E2020) has been introduced for the inhibition of …

Abstract Neurodegenerative diseases (Alzheimer's, Parkinson's etc.) causes brain cell
damage leading to dementia. The major restriction remains in delivering drug to the central …

The blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic
compounds. Pharmacological investigations have demonstrated the important biological …

Long-term potentiation (LTP) at the basal-dendritic synapses of CA1 pyramidal cells was
induced by a single 200 Hz stimulation train (0.5-1 sec duration) in freely behaving rats …

Cerebrovascular and neurodegenerative disorders affect one billion people around the
world and result from a combination of genomic, epigenomic, metabolic, and environmental …

Alzheimer disease (AD) is a progressive neurodegenerative disease, which is characterized
by loss of memory and cognitive function. In AD patients dysfunction of the cholinergic …