Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Purpose Mutations within the KRAS proto-oncogene have predictive value but are of
uncertain prognostic value in the treatment of advanced colorectal cancer. We took …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

Purpose: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major
drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with …

Recent literature suggests an increasing incidence of colorectal carcinoma in young
patients. We performed a histologic, molecular, and immunophenotypic analysis of patients …

Mucinous differentiation is associated with both CpG island methylator phenotype and
microsatellite instability in colorectal cancer. The mucinous phenotype derives from …