Drug‐resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs
and have contributed significantly to the failure to control and eradicate malaria throughout …

Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Atovaquone, a substituted hydroxynaphthoquinone, is a potent antimalarial drug that acts by
inhibiting the parasite's mitochondrial cytochrome bc 1 complex (cyt bc 1). Mutations in cyt …

Background. The return of chloroquine-sensitive Plasmodium falciparum to the limited area
of Blantyre, Malawi, has been well demonstrated in several studies. Methods. To …

Background Drug resistance is one of the greatest challenges of malaria control programme
in Mali. Recent advances in next-generation sequencing (NGS) technologies provide new …

Changing treatment practices may be selecting for changes in the drug sensitivity of malaria
parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated …

Malaria, a parasite vector-borne disease, is one of the biggest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …

Background Usage of chloroquine was discontinued from the treatment of Plasmodium
falciparum infection in almost all endemic regions because of global spread of resistant …

Background. Analysis of genome-wide polymorphism in many organisms has potential to
identify genes under recent selection. However, data on historical allele frequency changes …

Background Melanoma is a malignant cancer that affects melanocytes and is considered the
most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year …