The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Neurodegenerative diseases (NDs) are characteristic with progression of neuron
degeneration, resulting in dysfunction of cognition and mobility. Many neurodegenerative …

We developed a first-in-class proteolysis targeting chimera (PROTAC) for selective
degradation of histone deacetylase 8 (HDAC8). The PROTAC induced degradation of …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77
members known in the human, most of which consist of a RING-finger domain, one or two B …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

The success of inhibitor-based therapeutics is largely constrained by the acquisition of
therapeutic resistance, which is partially driven by the undruggable proteome. The …

Highlights•PROTACs are novel class of molecules efficiently degrades pathogenic
protein.•Due to large hydrophobic structure, PROTACs are usually considered bRo5 …

The technology known asPROTACs (PROteolysisTArgeting Chimeras) is a method of
protein degradation. Utilising bifunctional small molecules, the ubiquitin-proteosome system …