Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Prostate cancer is a major health issue in western countries and is the second leading
cause of cancer death in American men. Prostate cancer depends on the androgen receptor …

Drug resistance continues to be a major problem associated with cancer treatment. One of
the primary causes of anticancer drug resistance is the frequently mutated RAS gene. In …

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of
cancer. Over the past few decades, significant progress has been made in the development …

Classical targeting in cancer focuses on the development of chemical structures able to bind
to protein pockets with enzymatic activity. Some of these molecules are designed to bind the …

Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of
cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome …

Ferroptosis is a new type of regulated, non-apoptotic cell death driven by iron-dependent
phospholipid peroxidation. Inducing cell ferroptosis by inactivating glutathione peroxidase 4 …

Receptor‐like proteins (RLPs) lacking the cytoplasmic kinase domain play crucial roles in
plant growth, development and immunity. However, what remains largely elusive is whether …

The success of inhibitor-based therapeutics is largely constrained by the acquisition of
therapeutic resistance, which is partially driven by the undruggable proteome. The …

Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …