In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs)
regulate multiple cellular processes through mediating the activity of non-histone protein …

Osteosarcoma (OS) is the most common primary malignant bone tumor, which usually
occurs in children and adolescents. It is generally a high-grade malignancy presenting with …

The androgen receptor (AR) is a steroid hormone receptor widely detected in breast cancer.
Evidence suggests that the AR might be a tumor suppressor in estrogen receptor alpha …

Estrogen receptor a (ER), encoded by the ESR1 gene, is a nuclear receptor transcription
factor whose cognate ligand is estradiol. Following estradiol binding to ER, the receptor …

Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

Introduction Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a
ubiquitously expressed, non-receptor protein tyrosine phosphatase encoded by the PTPN11 …

Several small-molecule covalent inhibitors of KRAS G 12 C have made breakthrough
progress in the treatment of KRAS mutant cancer. However, the clinical application of KRAS …

Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …

The PROteolysis TArgeting Chimeras (PROTACs) is an innovative technique for the
selective degradation of target proteins via the ubiquitin–proteasome system. Compared …

Parkinson's disease (PD) is a common chronic neurodegenerative disease, and the heat
shock proteins (HSPs) are proved to be of great value for PD. In addition, HSPs can maintain …