Abstract Proteolysis Targeting Chimeras (PROTACs) based on multi-target inhibitors have
been reported several times recently. The advantages of PROTACs technology and the …

Receptor‐like proteins (RLPs) lacking the cytoplasmic kinase domain play crucial roles in
plant growth, development and immunity. However, what remains largely elusive is whether …

Abstract Purpose Estrogen Receptor α (ERα) is a well-established therapeutic target for
Estrogen Receptor (ER)-positive breast cancers. Both Selective Estrogen Receptor …

Simple Summary In this review paper, we focused on the discussion of various important
aspects of hormone receptor (HR)-positive breast cancer, including HR structure and …

The high prevalence of sarcopenia in an aging population has an underestimated impact on
quality of life by increasing the risk of falls and subsequent hospitalization. Unfortunately, the …

Phthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent
position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide …

Highlights•DDR1 plays a crucial role in regulating essential cellular physiological
activities.•Limitations of current DDR1 therapeutic approaches are discussed.•The reasons …

Simple Summary Rhabdomyosarcoma is the most common soft tissue cancer in children
and adolescents. Its resemblance to skeletal muscle tissue distinguishes …

SHP2 is a member of the non-receptor protein tyrosine phosphatases, encoded by PTPN11,
and exhibits oncogenic activities. The close association between SHP2 and human cancer …

Ubiquitination defects have been reported in various diseases, including neurodegenerative
diseases, metabolic disorders and cancer. Balance between degradation and synthesis of …