The participation of extracellular vesicles in many cellular processes, including reproduction,
is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles …

The bone marrow (BM) microenvironment regulates the properties of healthy hematopoietic
stem cells (HSCs) localized in specific niches. Two distinct microenvironmental niches have …

Cell-surface proteins are of great biomedical importance, as demonstrated by the fact that
66% of approved human drugs listed in the DrugBank database target a cell-surface protein …

CD82, a member of the tetraspanin superfamily, has been proposed to exert its activity via
tetra‐transmembrane protein enriched microdomains (TEMs) in exosomes. The present …

Exosomes are cell–cell communicators emerging as a new paradigm for noninvasive
diagnosis and prognosis of treatment response. Exosomal tetraspanin proteins like CD63 …

Communication between tumor cells and stromal cells is crucial to tumor development and
progression. Fibroblasts and macrophages are the most common stromal cells in the tumor …

Lactation persistency (LP), defined as the rate of declining milk yield after milk peak, is an
economically important trait for dairy cattle. Improving LP is considered a good alternative …

Transmembrane 4 L six family 1 (TM4SF1) is a protein with four transmembrane domains
that belongs to the transmembrane 4 L six family members (TM4SFs). Structurally, TM4SF1 …

Background Tetraspanins are members of the 4-transmembrane protein superfamily
(TM4SF) that function by recruiting many cell surface receptors and signaling proteins into …

The importance of molecular re-characterization of metastatic disease with the purpose of
monitoring tumor evolution has been acknowledged in numerous clinical guidelines for the …