The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …

Cancer is one of the leading causes of mortality in the developed countries. The search for
novel drug candidates is a priority goal for cancer therapy. However, the emergence of drug …

Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive
breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or …

Nasopharyngeal carcinoma (NPC) is a cancer with a high metastatic rate and poor
prognosis. Growing studies suggest that ferroptosis take part in the development of tumours …

Membrane transporters (such as ABCs, SLCs and ATPases) act in carcinogenesis and
chemoresistance development, but their relevance for prognosis of epithelial ovarian cancer …

The expression of ATP-binding cassette transporter (ABC transporters) has been reported in
various tissues such as the lung, liver, kidney, brain and intestine. These proteins account …

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7
and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down …

Microtubules are vitally important for eukaryotic cell division. Therefore, we evaluated the
relevance of mitotic kinesin KIF14, protein-regulating cytokinesis 1 (PRC1), and citron …

Background. Brain metastases are a very common neurological sequela in cancer patients.
The ability of current anticancer therapies to prolong overall survival is beleaguered by this …

Background Multidrug resistance-associated protein 1 (MRP1), encoded by the ABCC1
gene, is an ATP-binding cassette transporter mediating efflux of organic anions and …