The rapid progress in the field of deep learning has had a significant impact on protein
design. Deep learning methods have recently produced a breakthrough in protein structure …

The recent success of AlphaFold2 (AF2) and other deep learning (DL) tools in accurately
predicting the folded three-dimensional (3D) structure of proteins and enzymes has …

Thermostability is an essential requirement for the use of enzymes in the bioindustry. Here,
we compare different protein stabilization strategies using a challenging target, a stable …

The acquisition of a thermostable enzyme is an indispensable prerequisite for its successful
implementation in industrial applications and the development of novel functionalities …

Protein misfolding and aggregation involve complex cellular processes with clinical
implications in various diseases. However, the detection of aggregated proteomes without …

Nanozymes were introduced approximately 15 years ago as inorganic materials capable of
mimicking the catalytic abilities of natural (protein-based) enzymes. While the catalytic …

d-Glucaric acid (GA), one of the polyhydroxy dicarboxylic acids, is known for its great
potentials in the polymer, food, detergent, and pharmaceutical industries. Here, we …

Accurate understanding of the biological functions of enzymes is vital for various tasks in
both pathologies and industrial biotechnology. However, the existing methods are usually …

Protein kinases are key actors of signaling networks and important drug targets. They cycle
between active and inactive conformations, distinguished by a few elements within the …

Pyridoxine, also known as vitamin B6, is an essential cofactor in numerous cellular
processes. Its importance in various applications has led to a growing interest in optimizing …