Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

Bacterial pneumonia greatly contributes to the disease burden and mortality of lower
respiratory tract infections among all age groups and risk profiles. Therefore, laboratory …

Chronic rhinosinusitis (CRS) represents a heterogeneous disorder primarily characterized
by the persistent inflammation of the nasal cavity and paranasal sinuses. The subtype …

Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in
nutrient recycling and as a mechanism of innate immunity. Previously, we reported a novel …

Akt is an important kinase in metabolism. Akt also phosphorylates and activates endothelial
and neuronal nitric oxide (NO) synthases (eNOS and nNOS, respectively) expressed in M0 …

Abstract Background The role of Akt in nasal immunity is unstudied. Akt phosphorylates and
activates endothelial nitric oxide synthase (eNOS) expressed in epithelial ciliated cells. Nitric …

Bitter (T2R) and sweet/umami (T1R) taste receptors serve diverse chemosensory roles all
over the body. In airway motile cilia, T2Rs detect bacterial quinolones and lactones to …

Elexacaftor-tezacaftor-ivacaftor increases airway nitric oxide in children with cystic fibrosis
Elexacaftor-tezacaftor-ivacaftor increases airway nitric oxide in children with cystic fibrosis J …

Bitter taste receptors (T2Rs), are a subset of G protein-coupled receptors (GPCRs) that play
a key role in responding to microbial presence at epithelial surfaces. In epithelia, the …

Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in
nutrient recycling and as a mechanism of innate immunity. Previously, we reported a novel …