Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions

AE Peters, J Tromp, SJ Shah, CSP Lam… - Cardiovascular …, 2022 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with
complex pathophysiology and manifestations. Phenomapping is the process of applying …

Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox

JH Butt, MC Petrie, PS Jhund, N Sattar… - European heart …, 2023 - academic.oup.com
Aims Although body mass index (BMI) is the most commonly used anthropometric measure,
newer indices such as the waist-to-height ratio, better reflect the location and amount of …

Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction

A Uijl, G Savarese, I Vaartjes… - European journal of …, 2021 - Wiley Online Library
Aims We aimed to derive and validate clinically useful clusters of patients with heart failure
with preserved ejection fraction (HFpEF; left ventricular ejection fraction≥ 50%). Methods …

Diagnosis of obesity based on body composition‐associated health risks—Time for a change in paradigm

A Bosy‐Westphal, MJ Müller - Obesity Reviews, 2021 - Wiley Online Library
Traditional diagnosis and understanding of the pathophysiology of obesity are based on
excessive fat storage due to a chronically positive energy balance characterized by body …

[HTML][HTML] Epidemiology and clinical features of heart failure with preserved ejection fraction

K Teramoto, THK Teng, C Chandramouli… - Cardiac failure …, 2022 - ncbi.nlm.nih.gov
Heart failure (HF) with preserved ejection (HFpEF) constitutes a large and growing
proportion of patients with HF around the world, and is now responsible for more than half of …

The upcoming epidemic of heart failure in South Asia

P Martinez-Amezcua, W Haque, R Khera… - Circulation: Heart …, 2020 - Am Heart Assoc
Currently, South Asia accounts for a quarter of the world population, yet it already claims≈
60% of the global burden of heart disease. Besides the epidemics of type 2 diabetes mellitus …

Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index

C Adamson, PS Jhund, KF Docherty… - European journal of …, 2021 - Wiley Online Library
Aims In heart failure with reduced ejection fraction (HFrEF), there is an 'obesity paradox',
where survival is better in patients with a higher body mass index (BMI) and weight loss is …

Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: A cohort study

SC Chien, C Chandramouli, CI Lo, CF Lin… - PLoS …, 2021 - journals.plos.org
Background Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is
associated with adverse cardiac remodeling in the general population. Little is known about …

Associations between abdominal obesity indices and nonalcoholic fatty liver disease: Chinese visceral adiposity index

X Chen, F Shi, J Xiao, F Huang, F Cheng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease
worldwide. Up to 70%–80% of patients with NAFLD were obese, especially abdominal …