Targeting early infection to prevent HIV-1 mucosal transmission
AT Haase - Nature, 2010 - nature.com
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
A review of female genital schistosomiasis
EF Kjetland, PDC Leutscher, PD Ndhlovu - Trends in parasitology, 2012 - cell.com
In a review of the studies on genital schistosomiasis, the cervix, the Fallopian tubes, and the
vagina are the most common gynaecological sites to harbour Schistosoma haematobium …
vagina are the most common gynaecological sites to harbour Schistosoma haematobium …
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
While several clinical studies have shown that HIV-1 infection is associated with increased
permeability of the intestinal tract, there is very little understanding of the mechanisms …
permeability of the intestinal tract, there is very little understanding of the mechanisms …
Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota
B Shannon, TJ Yi, S Perusini, P Gajer, B Ma… - Mucosal …, 2017 - nature.com
Cervical human papillomavirus (HPV) infection may increase HIV risk. Since other genital
infections enhance HIV susceptibility by inducing inflammation, we assessed the impact of …
infections enhance HIV susceptibility by inducing inflammation, we assessed the impact of …
Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission
High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1
transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no …
transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no …
Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis–associated bacteria rather than lactobacilli
E Armstrong, A Hemmerling, S Miller… - The Journal of …, 2022 - Am Soc Clin Investig
Background Bacterial vaginosis (BV) causes genital inflammation and increases HIV risk,
whereas a vaginal microbiota dominated by Lactobacillus species is associated with …
whereas a vaginal microbiota dominated by Lactobacillus species is associated with …
HIV and mucosal barrier interactions: consequences for transmission and pathogenesis
A Burgener, I McGowan, NR Klatt - Current opinion in immunology, 2015 - Elsevier
Highlights•Mucosal barrier dysfunction is a key component of HIV transmission and
pathogenesis.•Inflammation results in mucosal damage, target cell accumulation, and …
pathogenesis.•Inflammation results in mucosal damage, target cell accumulation, and …
HIV incidence among men who have sex with men after diagnosis with sexually transmitted infections
DA Katz, JC Dombrowski, TR Bell… - Sexually transmitted …, 2016 - journals.lww.com
Background Men who have sex with men (MSM) are at high risk for acquiring HIV infection
after diagnosis with other sexually transmitted infections (STIs). Identifying the STIs …
after diagnosis with other sexually transmitted infections (STIs). Identifying the STIs …
Distinct effects of the cervicovaginal microbiota and herpes simplex type 2 infection on female genital tract immunology
B Shannon, P Gajer, TJ Yi, B Ma… - The Journal of …, 2017 - academic.oup.com
Background. Genital inflammation is a key determinant of human immunodeficiency virus
(HIV) transmission, and may increase HIV-susceptible target cells and alter epithelial …
(HIV) transmission, and may increase HIV-susceptible target cells and alter epithelial …
Persistent HIV RNA shedding in semen despite effective antiretroviral therapy
Effective antiretroviral therapy (ART) may reduce HIV sexual transmission by lowering
genital HIV levels. A prospective study of men starting ART (n= 25) demonstrated rapid …
genital HIV levels. A prospective study of men starting ART (n= 25) demonstrated rapid …