Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …

Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which
seriously reduces the quality of life of patients and places a heavy economic burden on their …

The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …

During Inflammaging, a dysregulation of the immune cell functions is generated, and these
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …