Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis

D Edessa, M Sisay, F Asefa - PloS one, 2019 - journals.plos.org
Background Increased second-line antiretroviral therapy (ART) failure rate narrows future
options for HIV/AIDS treatment. It has critical implications in resource-limited settings; …

The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030

E Ndashimye, EJ Arts - Infectious Diseases of Poverty, 2019 - mednexus.org
Background: Over 90% of Human Immunodeficiency Virus (HIV) infected individuals will be
on treatment by 2020under UNAIDS 90-90-90 global targets. Under World Health …

Third-line antiretroviral therapy program in the South African public sector: cohort description and virological outcomes

M Moorhouse, G Maartens, WDF Venter… - JAIDS Journal of …, 2019 - journals.lww.com
Background: The World Health Organization recommends that antiretroviral therapy (ART)
programs in resource-limited settings develop third-line ART policies. South Africa …

Protease inhibitor resistance in the first 3 years of second-line antiretroviral therapy for HIV-1 in sub-Saharan Africa

TS Boender, RL Hamers, P Ondoa… - The Journal of …, 2016 - academic.oup.com
Background. As antiretroviral therapy (ART) programs in sub-Saharan Africa mature,
increasing numbers of persons with human immunodeficiency virus (HIV) infection will …

HIV-1 second-line failure and drug resistance at high-level and low-level viremia in Western Kenya

R Kantor, A DeLong, L Schreier, M Reitsma, E Kemboi… - Aids, 2018 - journals.lww.com
Objective: Characterize failure and resistance above and below guidelines-recommended
1000 copies/ml virologic threshold, upon second-line failure. Design: Cross-sectional study …

HIV-1 drug resistance and third-line therapy outcomes in patients failing second-line therapy in Zimbabwe

C Chimbetete, D Katzenstein, T Shamu… - Open forum …, 2018 - academic.oup.com
Objectives To analyze the patterns and risk factors of HIV drug resistance mutations among
patients failing second-line treatment and to describe early treatment responses to …

Outcome of patients on second line antiretroviral therapy under programmatic condition in India

J Chakravarty, S Sundar, A Chourasia, PN Singh… - BMC infectious …, 2015 - Springer
Abstract Background The National AIDS Control Organization of India has been providing
free second line antiretroviral therapy (ART) since 2008. This observational study reports the …

Third-line antiretroviral therapy in Africa: effectiveness in a Southern African retrospective cohort study

G Meintjes, L Dunn, M Coetsee, M Hislop… - AIDS Research and …, 2015 - Springer
Background An increasing number of patients in Africa are experiencing virologic failure on
second-line antiretroviral therapy (ART) and those who develop resistance to protease …

Virological failure and HIV drug resistance among adults living with HIV on second‐line antiretroviral therapy in the Asia‐Pacific

J Ross, A Jiamsakul, N Kumarasamy, I Azwa… - HIV …, 2021 - Wiley Online Library
Objectives To assess second‐line antiretroviral therapy (ART) virological failure and HIV
drug resistance‐associated mutations (RAMs), in support of third‐line regimen planning in …

Timeliness of point-of-care viral load results improves human immunodeficiency virus monitoring in Nigeria

B Chaplin, O Agbaji, H Reyes Nieva… - Clinical Infectious …, 2023 - academic.oup.com
Background Human immunodeficiency virus (HIV) viral load (VL) monitoring is critical for
antiretroviral therapy (ART) management. Point-of-care (POC) VL testing has been reported …